![]() Indeed, they have been used for transgenesis and insertional mutagenesis in different organisms, since these elements are not generally dependent on host factors to mediate their mobility. As genetic tools, DNA transposons can be used to introduce a piece of foreign DNA into a genome. They are powerful forces of genetic change and have played a significant role in the evolution of many genomes. DNA transposons move from one genomic location to another by a cut-and-paste mechanism. Repeated DNA makes up a large fraction of a typical mammalian genome, and some repetitive elements are able to move within the genome (transposons and retrotransposons).
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